Plenity weight-loss treatment yielding average results

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First came the “edible billboard,” which appeared last year during the holidays in New York’s East Village loaded with cake treats.

Then, in late January, came the national marketing campaign, with TV and digital media promoting the idea that trying to lose weight doesn’t mean a person can’t enjoy eating.

Those advertising messages are pushing a product named Plenity as a potential liberation from dieters’ woes. It’s a $98-a-month weight-loss treatment that looks like a drug, with people taking three capsules twice a day. But it isn’t a drug.

And its success in racking up lost pounds, on average, is modest.

Plenity is approved by the federal Food and Drug Administration as a medical device, one that contains sugar-sized grains of a plant-based, absorbent hydrogel. Each grain swells to 100 times its size, cumulatively filling about a quarter of a person’s stomach. The three capsules containing them must be taken with two cups of water at least 20 minutes before eating. The gel is not absorbed and eventually exits the body in stool.

The treatment generally isn’t covered by insurance.

“We thought we would price it low enough that most consumers can pay out-of-pocket,” said Dr. Harry Leider, chief medical officer and executive vice president of Gelesis, the maker of Plenity.

Though far less costly than some other prescription weight-loss treatments, it still “isn’t affordable for someone in the low-income bracket,” said Jena Shaw Tronieri, an assistant professor and director of clinical services at the University of Pennsylvania’s Center for Weight and Eating Disorders.

Plenity is designed to help people who want to eat less, and taking it is comparable to consuming a big salad before lunch and dinner, though without the actual raw vegetables.

It joins a growing selection of prescription weight-loss and obesity treatments, ranging from old-school oral medications that often are low-cost generics to far pricier brand-name injectable diabetes drugs newly repurposed as weight-loss treatments. Results varied widely among trial participants, with 59% of those taking Plenity losing at least 5% of their body weight. The rest did not meet that threshold.

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Plenity, whose active ingredient is a form of cellulose, embraces a strategy that has been used for decades by some people: to feel full before eating a main meal, thus reducing the calories they take in. Studies have shown that, “If you fill up on broth-based soup or vegetables before a meal, you will feel fuller and eat less,” said Tronieri, noting that filling up with water doesn’t produce the same satiating effect.

Still, some patients say they “hate vegetables” and that “capsules are a lot easier,” said Dr. Christina Nguyen, medical director of obesity medicine at Northeast Georgia Health System, who isn’t affiliated with Gelesis but has been prescribing Plenity since its soft launch in late 2020.

Gelesis credits the marketing campaign with …read more

Source:: Chicago Sun Times

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